Convergent total syntheses of fluvibactin and vibriobactin using molybdenum(VI) oxide-catalyzed dehydrative cyclization as a key step.
نویسندگان
چکیده
Efficient total syntheses of fluvibactin and vibriobactin have been achieved via molybdenum(VI) oxide-catalyzed dehydrative cyclization, Sb(OEt)(3)-catalyzed ester-amide transformation, and WSCI and HOAt-promoted dehydrative amide formation.
منابع مشابه
Cobalt(III)-Catalyzed Synthesis of Indazoles and Furans by C–H Bond Functionalization/Addition/Cyclization Cascades
The development of operationally straightforward and cost-effective routes for the assembly of heterocycles from simple inputs is important for many scientific endeavors, including pharmaceutical, agrochemical, and materials research. In this article we describe the development of a new air-stable cationic Co(III) catalyst for convergent, one-step benchtop syntheses of N-aryl-2H-indazoles and f...
متن کاملTotal synthesis of dendrobate alkaloid (+)-241D, isosolenopsin and isosolenopsin A: application of a gold-catalyzed cyclization.
A new approach to total syntheses of piperidine alkaloids (+)-241D, isosolenopsin and isosolenopsin A has been developed from D-alanine. The key step to access the chiral pyridinone intermediate was achieved via a gold mediated cyclization. Finally, various reduction conditions afforded the natural products in few steps and good overall yields.
متن کاملAn alkyne hydroacylation route to highly substituted furans.
transforming relatively complex starting materials into substituted heterocycles, and for the functionalization of existing heterocycles, there is less precedent for methodology which involves the direct, regiodefined synthesis of highly substituted heterocycles from simple starting materials. As such, new methods for the synthesis of substituted heterocycles (or their precursors) are potential...
متن کاملNovel Method for Stripping of Molybdenum (VI) after its Extraction with Cyanex 301
Hydrofluoric acid has been used as a novel stripping agent for molybdenum (VI) after its extraction with Cyanex 301. In the extraction steps effects of parameters such as type and initial concentration of acid, type of diluent, extractant concentration, metal concentration and temperature have been studied. In thestripping step, the effects of various stripping agents on stripping efficiency ha...
متن کاملCarbohydrates to Pyrano-Furanoids: New and Regioselective Palladium-Catalyzed Syntheses of Tetrasubstituted Furanoids from Carbohydrate Scaffolds
Furanoids are important targets either as a key entity itself or as a substructure that represents the framework of many biologically significant natural products [1]. Therefore, their access has attracted the interest of many groups [2], Voelter et al. have described elegant strategies for the syntheses of furanoids using two different approaches, either mono or dianions derived from 1,3-dicar...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Chemical communications
دوره 30 شماره
صفحات -
تاریخ انتشار 2008